Diabetes and cardiovascular disease are big global health issue. Each year, 17.7 million people die from cardiovascular disease, accounting for 30% of the global death. Diabetes is a chronic disease, but the horrible thing is the complications. Among them, diabetic patients are more likely lead to hyperlipidemia situation than normal people, and long-term abnormal accumulation of blood lipids will cause a variety of cardiovascular diseases.
The Assessment Method for the Effect of Healthy Foods that Do Not Form Body Fat released by the Ministry of Health and Welfare was referenced for studying obesity in rodent models. Daily doses of Insumate® bitter melon peptide at 10.42 mg/kg and commercially available bitter melon extract 52.08 mg/kg (dose for large mice) were administered for 8 continuous weeks.